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BioAnalix platforms

Protein & enzyme stability engineering

An iterative platform for identifying protein variants that retain function under heat, storage and process stress.

The platform at a glance

Design for the stress.
Test for the function.

Conceptual workflow
01 / Sequence design
Starting sequence
AGLKSV
Candidate variant
AGLKTV

Explore a change

Prioritize variants worth testing.

02 / Controlled stress
Heat
Storage
Process

Challenge the protein

Use conditions relevant to its application.

03 / Functional readout
StabilityRetained activity

Measure both

Compare against the starting protein.

Illustrative sequence fragment and workflow—not a specific protein, assay or experimental result.

The challenge

Stability is useful only when function survives.

Proteins and enzymes can lose activity during storage, transport or processing. Our program explores how sequence design and experimental screening can identify variants that better tolerate those stresses—without losing the function an application depends on.

Our development approach

From a biological question to a measured result.

  1. 01 / Define

    Start with the application

    Agree on the target protein, required function and relevant heat, storage or process conditions.

  2. 02 / Screen

    Build experimental evidence

    Generate protein-specific measurements through controlled stress screening and reference samples.

  3. 03 / Learn

    Prioritize candidate variants

    Use experimental data and AI-guided modelling to investigate sequence changes worth testing.

  4. 04 / Validate

    Measure what matters

    Compare selected variants against the baseline, checking stability alongside retained function.

Every experiment informs the next design.

Predictions guide experiments; they do not replace validation.

Potential applications

Designed around the demands of your protein.

Diagnostic reagents

Explore stability under storage and handling conditions relevant to assay reliability.

Industrial enzymes

Investigate retained activity under application-specific heat and process stress.

Biologics research

Evaluate stability questions in research-stage proteins. Clinical suitability is outside the scope of research validation.

Validation priorities

Evidence before performance claims.

  • Assay repeatability and appropriate controls.
  • Predicted versus experimentally measured stability.
  • Candidate performance relative to the starting protein.
  • Retention of the biological function required by the application.
  • Transferability assessed across proteins—not assumed.
Retained function
Function retained
Stability limited
Development
target
Revisit design
Stable, but
function limited
Increasing stability
Conceptual evaluation map · no experimental data

Reducing cold-chain dependence is a potential long-term benefit, not an established outcome of the platform.

Working with BioAnalix

A clear scope before the first experiment.

Begin with your target protein, intended use and stability challenge. We can discuss feasibility, suitable measurements and a staged research scope. Depending on the agreed project, outputs may include ranked candidates, experimental comparisons and recommendations for further evaluation.

Proprietary sequences, methods and technical details can be discussed under a non-disclosure agreement. Please do not include confidential material in an initial email.

Explore related protein-engineering publications

Let’s define the next step.

Tell us about your application, the challenge you need to solve and what a useful outcome would look like.

Talk to BioAnalix