Antibodies

Reliable and well-selected antibodies are among the most effective tools available to researchers when it comes to identifying and locating specific proteins. Increasingly, antibodies have been employed to directly diagnose and treat diseases.

BioAnalix provides a broad range of high-quality Primary and Secondary antibodies. These products can be applied to all areas of biological research and drug discovery. All our antibodies are thoroughly tested to ensure the highest level of specificity, sensitivity, and reproducibility.

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    Antibodies

    IgA Antibody

     Original price was: $780.00.Current price is: $650.00. Add to cart

    IgA antibody is the most abundant antibody class in human serum and has a unique role in mediating immunity. IgA is a polyvalent antibody that is translocated to mucosal surfaces as the first line of defence against infections. Most of the secreted IgA lines the mucosal surfaces including respiratory, digestive and genitourinary tracts to protect against pathogens while maintaining gut homeostasis.

    The importance of IgA in pathogen defence is highlighted by the numerous mechanisms used by pathogens to neutralize sIgAs, including sIgA-binding proteins and sIgA-specific proteases produced by certain pneumococci, neisseriae and haemophilus species of bacteria.

    IgA Antibody Structure and Format

    IgA antibodies consists of heavy (H) and light (L) chains. Each H chain is comprised of the Constant region (Cα1, Cα2, Cα3), hinge region and the Variable (V) region. Light chains consists of the CL and Vκ or Vλ elements. Altogether the combined molecular weight of IgA antibody is ~160 kDa. IgA antibodies possess a unique 18-amino acid tail piece at the C-terminus of the H chains which is key for oligomerization. As in the case of IgM antibody, IgA antibody monomers routinely dimerize with the help of a 15 kDa J chain. The secreted form of IgA (sIgA) is usually dimeric and contains an additional 80-85 kDa component.

  • Antibodies

    IgM Antibody

     $820.00 Add to cart

    The IgM class of antibodies recognizes a large variety of pathogenic antigens and is highly active in cytotoxic and cytolytic reactions due to its superior activation of the complement system. IgM antibody has applications in Antibody Drug Discovery. Just a few reasons why IgM antibody can be an attractive therapeutic are listed below.

    • IgM antibody can make a good biologic against cancer owing to its strong avidity as well as complement fixation property.
    • For certain targets, particularly those such as glycol-epitopes on cancer cells, an IgM antibody might be the best approach.
    • An IgM antibody might also be useful as a vaccine adjuvant, acting as soluble toll-like receptors through the formation of immune complexes with antigen.
    • It has been suggested to use IgMs as preventive vaccine.
    • The innate ability of IgM to mediate autoimmunity can be utilized to ameliorate graft rejections during transplantation procedures.
    • The inflammatory control IgM antibody provides systemic exposure to self antigens could be harnessed to treat arthritis.

    Recent advancements have made IgM antibody amenable to manipulation that allows further tuning of its effector function to meet the above therapeutic needs. There are several requirements for IgM antibodies to be considered as a potential standard platform, including in vitro optimization, recombinant production, and purification. IgM antibody variable chains have been manipulated using phage display technology in vitro to optimize IgM therapeutic antibody candidates. Their recombinant yields in cell culture have been improved and methods for purification have been optimized. Based on these advances an IgM therapeutics platform can be built.

     

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    Antibodies

    Neuroscience Antibodies

     Original price was: $920.00.Current price is: $780.00. Add to cart

    The discovery of new potential drug targets, signaling molecules and structural proteins in the brain has dramatically increased the demand for high-quality neuroscience antibodies. The research on traditional targets and pathways will continue to focus on dopamine, beta amyloid, and serotonin. We offer a wide range of tools, including pan and phospho-specific antibodies as well as peptides and proteins geared toward different areas of neuroscience research. These antibodies, particularly those applicable to studies involving various pathways leading to neurological diseases, are among the bio-reagents keenly sought by neuroscience researchers.

    All BioAnalix neuroscience antibodies are carefully purified prior to delivery. Most of our production processes involve affinity chromatography purification based on the relevant epitope, further ensuring the quality of antibodies. BioAnalix has a comprehensive collection of antibodies targeting Alzheimer’s disease and other neurological diseases including Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis.

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