IgA Antibody

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  Antibodies

  IgA Antibody

  $780.00 Original price was: $780.00.$650.00Current price is: $650.00. Add to cart

  IgA antibody is the most abundant antibody class in human serum and has a unique role in mediating immunity. IgA is a polyvalent antibody that is translocated to mucosal surfaces as the first line of defence against infections. Most of the secreted IgA lines the mucosal surfaces including respiratory, digestive and genitourinary tracts to protect against pathogens while maintaining gut homeostasis.

  The importance of IgA in pathogen defence is highlighted by the numerous mechanisms used by pathogens to neutralize sIgAs, including sIgA-binding proteins and sIgA-specific proteases produced by certain pneumococci, neisseriae and haemophilus species of bacteria.

  IgA Antibody Structure and Format

  IgA antibodies consists of heavy (H) and light (L) chains. Each H chain is comprised of the Constant region (Cα1, Cα2, Cα3), hinge region and the Variable (V) region. Light chains consists of the C_L and Vκ or Vλ elements. Altogether the combined molecular weight of IgA antibody is ~160 kDa. IgA antibodies possess a unique 18-amino acid tail piece at the C-terminus of the H chains which is key for oligomerization. As in the case of IgM antibody, IgA antibody monomers routinely dimerize with the help of a 15 kDa J chain. The secreted form of IgA (sIgA) is usually dimeric and contains an additional 80-85 kDa component.